De-escalation of chemoradiotherapy in stage III NSCLC

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Written By Kampretz Bianca

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Special report|
Commissioned and funded by: AstraZeneca GmbH, Hamburg

Non-Small Cell Lung Cancer (NSCLC)

Immune checkpoint inhibition with durvalumab according to the PACIFIC regimen has been established as the gold standard for the treatment of unresectable stage III non-small cell lung cancer (NSCLC) in the absence of progression after platinum-based chemoradiotherapy ( RCT) and tumor PD- L1 expression ≥ is 1% [1–4]. However, in daily clinical practice, randomized controlled trials are sometimes not carried out simultaneously, but rather sequentially. The PACIFIC-6 study and other studies examined the tolerability and efficacy of a sequential RCT in patients who were not suitable for a simultaneous RCT for several reasons.

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